Drugs causing sexual dysfunction

Drugs that can cause sexual dysfunction are:

Drugs acting on the brain

Antidepressants like amitriptyline, amoxapine, clomipramine, doxepine, maprotiline, protriptyline, trazodone. The SSRI group of antidepressants that includes fluoxetine and sertraline are particularly notorious for causing sexual problems.

Antipsychotics like chlorpromazine, haloperidol, thioridazine and trifluoperazine

Antianxiety drugs like diazepam

Alcohol, opioids and cocaine


Drugs used to treat Parkinson’s disease like levodopa, benztropin, bromocriptine

Drugs used to treat seizures like carbamazepine, ethosuximide, phenytoin

Drugs used to treat hypertension like methyldopa, prazosin, clonidine, guanethidine and reserpine

Antihistamines like diphenhydramine, dimenhydrinate, hydroxyzine, meclizine, promethazine – Antihistamines cause drowsiness, and in females they also cause dryness of vagina leading to pain during sex.

Drugs that alter the effect of hormones

Spironolactone (an antihypertensive/ diuretic)

Cimetidine (an anti-ulcer drug)

Finasteride or dutasteride (used for prostate enlargement), cyproterone acetate – These drugs block the effects of androgens


GnRH analogues such as nafarelin, triptorelin, goserelin and leuprolide


Drugs used to treat high blood pressure

They may decrease blood pressure, thus decreasing the blood pressure in the penis during an erection

Diuretics like amiloride, indapamide, thiazide diuretics and spironolactone

Beta – blockers like atenolol, metoprolol

Alpha blockers like methyldopa, prazosin, terazosin, tamsulosin and clonidine

Adrenergic neuronal blockers like guanethidine and reserpine

Calcium channel blockers like verapamil

Among the antihypertensive drugs, ACE inhibitors like enalapril and ramipril are less likely to cause sexual dysfunction

Drugs used to treat abnormal heart rhythm or arrhythmias



Drugs used to treat high lipid level



Naproxen and ibuprofen

Anticancer drugS

No comments:

Post a Comment