Drugs that can cause sexual dysfunction are:
Drugs acting on the brain
Antidepressants like amitriptyline, amoxapine, clomipramine, doxepine, maprotiline, protriptyline, trazodone. The
SSRI group of antidepressants that includes fluoxetine and sertraline
are particularly notorious for causing sexual problems.
Antipsychotics like chlorpromazine, haloperidol, thioridazine and trifluoperazine
Antianxiety drugs like diazepam
Alcohol, opioids and cocaine
Amphetamines
Drugs used to treat Parkinson’s disease like levodopa, benztropin, bromocriptine
Drugs used to treat seizures like carbamazepine, ethosuximide, phenytoin
Drugs used to treat hypertension like methyldopa, prazosin, clonidine, guanethidine and reserpine
Antihistamines like diphenhydramine, dimenhydrinate, hydroxyzine, meclizine, promethazine – Antihistamines cause drowsiness, and in females they also cause dryness of vagina leading to pain during sex.
Drugs that alter the effect of hormones
Spironolactone (an antihypertensive/ diuretic)
Cimetidine (an anti-ulcer drug)
Finasteride or dutasteride (used for prostate enlargement), cyproterone acetate – These drugs block the effects of androgens
Estrogen
GnRH analogues such as nafarelin, triptorelin, goserelin and leuprolide
Ketoconazole
Drugs used to treat high blood pressure
They may decrease blood pressure, thus decreasing the blood pressure in the penis during an erection
Diuretics like amiloride, indapamide, thiazide diuretics and spironolactone
Beta – blockers like atenolol, metoprolol
Alpha blockers like methyldopa, prazosin, terazosin, tamsulosin and clonidine
Adrenergic neuronal blockers like guanethidine and reserpine
Calcium channel blockers like verapamil
Among the antihypertensive drugs, ACE inhibitors like enalapril and ramipril are less likely to cause sexual dysfunction
Drugs used to treat abnormal heart rhythm or arrhythmias
Amiodarone
Mexelitine
Drugs used to treat high lipid level
Clofibrate
Painkillers
Naproxen and ibuprofen
Anticancer drugS
Drugs acting on the brain Antidepressants like amitriptyline, amoxapine, clomipramine, doxepine, maprotiline, protriptyline, trazodone. The
SSRI group of antidepressants that includes fluoxetine and sertraline
are particularly notorious for causing sexual problems. Antipsychotics like chlorpromazine, haloperidol, thioridazine and trifluoperazine Antianxiety drugs like diazepam Alcohol, opioids and cocaine Amphetamines Drugs used to treat Parkinson’s disease like levodopa, benztropin, bromocriptine Drugs used to treat seizures like carbamazepine, ethosuximide, phenytoin Drugs used to treat hypertension like methyldopa, prazosin, clonidine, guanethidine and reserpine Antihistamines like diphenhydramine, dimenhydrinate, hydroxyzine, meclizine, promethazine – Antihistamines cause drowsiness, and in females they also cause dryness of vagina leading to pain during sex. Drugs that alter the effect of hormones Spironolactone (an antihypertensive/ diuretic) Cimetidine (an anti-ulcer drug) Finasteride or dutasteride (used for prostate enlargement), cyproterone acetate – These drugs block the effects of androgens Estrogen GnRH analogues such as nafarelin, triptorelin, goserelin and leuprolide Ketoconazole Drugs used to treat high blood pressureThey may decrease blood pressure, thus decreasing the blood pressure in the penis during an erection
Diuretics like amiloride, indapamide, thiazide diuretics and spironolactone Beta – blockers like atenolol, metoprolol Alpha blockers like methyldopa, prazosin, terazosin, tamsulosin and clonidine Adrenergic neuronal blockers like guanethidine and reserpine Calcium channel blockers like verapamilAmong the antihypertensive drugs, ACE inhibitors like enalapril and ramipril are less likely to cause sexual dysfunction
Drugs used to treat abnormal heart rhythm or arrhythmias Amiodarone Mexelitine Drugs used to treat high lipid level Clofibrate Painkillers Naproxen and ibuprofen Anticancer drugS
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